The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study

Table 2 Patient samples used for sequencing and MALDI TOF

Samples	Total	aGPA	inGPA	DC	HC	HHC	Longitudinal
V1 V2 16S^a	59	7	31	2	7	4 (3 patients)	8 (7 patients)
Shotgun sequenced	96	12	43	13	11	5 (4 patients)	12 (11 patients)
MALDI-TOF	83	10	36	12	0	3	9
Cultured S. aureus	32	8	15	3	2	1	2
Cultured S. warneri	15	1	4	5	2	1	2
Cultured S. pasteuri	3	0	3	0	0	0	0
Cultured S. capitis	11	1	5	3	2	0	0
Cultured S. epidermidis	13	0	7	1	3	1	1
Cultured S. pseudintermedius	4	0	2	0	0	0	2 (1 patient)
Cultured S. haemolyticus	17	0	8	4	2	1	2
Cultured S. caprae	1	1	0	0	0	0	0
Cultured S. saphrophyticus	1	0	1	0	0	0	0
Cultured S. lugdunensis	2	0	1	0	1	0	0
Cultured S. simulans	1	0	0	1	0	0	0
Cultured S. pettenkoferi	1	0	0	0	1	0	0

Abbreviations: aGPA active granulomatosis with polyangiitis, inGPA inactive GPA, DC disease controls (microscopic polyangiitis and eosinophilic GPA), HC healthy controls, HHC healthy household controls, MALDI-TOF matrix-assisted laser desorption/ionisation–time-of-flight mass spectrometry
^aFor the bacterial 16S rRNA sequencing project, we sequenced the bacterial 16S rRNA variable region v1 and v2

ISSN: 2049-2618