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Table 1 Clinical characteristic of patients and controls

From: The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study

Participant characteristics Total subjects Active GPA (aGPA) Inactive GPA (inGPA)a Disease controls: microscopic polyangiitis (MPA) and eosinophilic GPA (EGPA) Healthy controls (HC) Healthy household controls (HHC)
84 12 44 13 11 4
Age (years) 57.9 (17–73) 56.1 (42–73) 58.2 (17–87) 58.4 (42–76) 39.4 (23–58)  
Gender female 46.30% 50% 47.60% 38.50% 81.80% 50%
Gender male 53.70% 50% 52.40% 61.50% 18.20% 50%
Disease duration (months) 113.3 78 124.7 110.8   
BVAS WG 1.1 3.5 0.7 0.2   
VDI 2.0 2.1 1.5 3.5   
DEI 1.5 3.7 1.2 0.4   
Steroids 56.7% 75% 47.6% 69.2%   
Immunosuppressionb 59.7% 75% 57.1% 53.8%   
CRP (mg/dl) 7.6 14.2 7.4 2.2   
ESR (mm/h) 13.4 24.1 11 10.3   
eGFR (MDRD) 87.2 83.8 87.3 90.3   
Epistaxis 19.4% 83.3% 4.8% 7.7%   
Mucopurulent discharge 23.9% 100% 9.5% 0%   
Olfaction 19.4% 50% 7.1% 30.8%   
Crusting 37.3% 75% 38.1% 0%   
Inflammation 24.2% 100% 10.5% 0%   
Bloody discharge 16.1% 90.9% 0% 0%   
Nasal obstruction 16.1% 63.6% 7.9% 0%   
  1. Abbreviations: BVAS WG Birmingham Vasculitis Activity Score for Wegener’s Granulomatosis (WG, GPA), VDI Vasculitis Damage Index, DEI Disease Extent Index, CRP C-reactive protein, ESR erythrocyte sedimentation rate, eGFR estimated glomerular filtration rate, MDRD Modification of Diet in Renal Disease
  2. aInactive ear, nose and throat (ENT) GPA
  3. bWithin the year of sample collection