Fig. 2

Correlations between immune markers, immune cell counts, and outcomes in patients undergoing HSCT. a Pairwise Spearman’s correlation between immune markers and immune cell counts in HSCT patients (n = 37) that were determined to be significant in a permutational multivariate analysis of variance using (microbial) distance matrices (adonis) (See Table S2). Positive and negative correlations are represented by red or blue circles, respectively, and the size of circles and intensity of color refer to the strength of the correlation. Correlations that are significant (P ≤ 0.05) are indicated by a black outline of the circle. b Natural killer (NK) and total B cell (mature and immature) reconstitution in month + 2 with respect to the maximum acute GvHD (aGvHD) grade (0–I vs. II–IV) in HSCT patients (n = 37). hBD2_pre, hBD2_w0, hBD2_w1, hBD2_w2 plasma human beta-defensin 2 concentration pre-HSCT, on the day of HSCT, and in weeks + 1 and + 2, respectively; mono_pre, mono_w3 monocyte counts pre-HSCT and in week + 3, respectively; neutro_m3 neutrophil count in month + 3; CD8⁺_m1 CD8⁺ T cell counts in month + 1; Age recipient age at time point of transplantation; NK_m1, NK_m2 natural killer cell counts in months + 1 and + 2, respectively; B_m2, mat_B_m2, immat_B_m2 all, mature, and immature B cell counts in month + 2; CD4⁺_m2 CD4⁺ T cell counts in month + 2; Citr_pre, Citr_w1 plasma citrulline levels pre-HSCT and in week + 1, respectively; CRP, CRP_w1, CRP_w5, CRP_w6, CRP_m3, CRP_m6 C-reactive protein levels at time points simultaneous to microbiome characterization, in weeks + 1, + 5, and + 6, and in months + 3 and + 6, respectively. *P < 0.05; **P < 0.01, and ***P < 0.001