Skip to main content
Fig. 1 | Microbiome

Fig. 1

From: Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation

Fig. 1

Monitoring of the host immune system and intestinal microbiome in hematopoietic stem cell transplantation (HSCT). a Study outline. A cohort of 37 pediatric recipients of allogeneic HSCT was monitored prior to HSCT, at the time point of HSCT, and post-HSCT (median follow-up time 5.2 years). A range of patient characteristics as well as disease outcomes, immune markers, immune cell counts, and intestinal patterns of microbial community composition were recorded at the noted time points (up to 12 months post-HSCT). See Table S1 for details regarding the patient characteristics. b Plasma hBD2 concentrations over time and in comparison to healthy controls (young adults). The y-axis was log10-transformed for better visualization. Zeros were replaced with 1 to avoid undefined values on the log-transformed axis. Asterisks indicate whether the concentrations at each respective time point were significantly different from any of the other time points (showing the maximum significance level). c Bacterial alpha-diversity, measured by inverse Simpson index, of the intestinal microbiome shown with log10-transformed y-axis. d Relative abundances over time of the 8 most abundant taxonomic families in the dataset (comprising 98 fecal samples). *P < 0.05; **P < 0.01; and ***P < 0.001

Back to article page