Fig. 6

The bile acid producer, C. scindens, is associated with diet-induced remission in human pediatric Crohn’s disease. Analysis of public data [23] from human pediatric Crohn’s disease patients treated with exclusive enteral nutrition (EEN). Relative abundance of reads (mapping ratio) aligning to a C. scindens reference or b bai operon from 20 patient’s pretreatment and 1, 4, and 8 weeks following administration of EEN. Patients that responded to treatment and entered remission (n = 10, green) and those that failed therapy (n = 10, red) are shown. c, d Spearman’s correlations between log10-transformed fecal calprotectin levels (FCP) and relative abundance of C. scindens (R = − 0.351 for “Responsive,” P = 0.033; R = − 0.027 for “Non.Responsive,” P = 0.877) or bai operon (R = − 0.394 for “Responsive,” P = 0.016; R = 0.049 for “Non.Responsive,” P = 0.777). The shaded areas show the 95% confidence interval. e Schematic showing proposed model for microbiome alterations. ns, not significant. *P < 0.05, **P < 0.01, ***P < 0.001 using the two-sided Wilcoxon rank sum test for relative abundance comparisons