Table 1 Overview of primary and secondary bile acids. VMH Virtual Metabolic Human database (https://vmh.life) [16]. AGORA, a compendium of 818 curated genome-scale gut microbial metabolic reconstructions used in this study.
Name | Abbreviation | VMH ID | Type | Producer |
|---|---|---|---|---|
Taurocholate | Tauro-CA | tchola | Primary/conjugated | Human |
Glycocholate | Glyco-CA | gchola | ||
Taurochenodeoxycholate | Tauro-CDCA | tdchola | ||
Glycochenodeoxycholate | Glyco-CDCA | dgchol | ||
Cholate | CA | cholate | Primary/unconjugated | Human; released by 185/818 AGORA strains |
Chenodeoxycholate | CDCA | C02528 | ||
12-dehydrocholate | 12-dehydro-CA | 12dhchol | Secondary | 38/818 AGORA strains |
7-ketodeoxycholate | 7-keto-CA | 7ocholate | 41/818 AGORA strains | |
7-dehydrochenodeoxy-cholate | 7-dehydro-CDCA | 7dhcdchol | ||
3-dehydrocholate | 3-dehydro-CA | 3dhchol | 16/818 AGORA strains | |
3-dehydrochenodeoxy-cholate | 3-dehydro-CDCA | 3dhcdchol | ||
Isocholate | Iso-CA | isochol | 11/818 AGORA strains | |
Isochenodeoxycholate | Iso-CDCA | icdchol | ||
Lithocholate | LCA | HC02191 | 5/818 AGORA strains | |
Deoxycholate | DCA | dchac | ||
Allolithocholate | allo-LCA | alchac | ||
Allodeoxycholate | allo-DCA | adchac | ||
Ursocholate | UCA | uchol | 3/818 AGORA strains | |
Ursodeoxycholate | UDCA | HC02194 |