Fig. 7

Bacterial communities that covariated with lipoperoxidation status and metabolites. a Relative abundance of bacterial taxa (12) that strongly covariated with haem lipoperoxidation status. b CIM of 12 previously selected bacterial taxa and 19 physiological traits (metadata) selected with rCCA. c Relevance network of 12 bacterial taxa, metadata, and metabolites selected with DIABLO framework. Only associations with an absolute correlation > 0.75 are represented. Red and blue colours indicate regions where bacterial taxa, metadata, and metabolites are highly positively and negatively correlated, respectively. CON, control diet; Ca, control diet + calcium carbonate; HEM, haem-enriched diet; HEM-Ca, haem-enriched diet + calcium carbonate; DHNMA, urinary 1,4 dihydroxynonenal; Haem, haem in faecal water; TBARS, faecal thiobarbituric reactive substances; Genotoxicity, DNA damage by comet assay; iKB, ikappaB; IL10, IL10 in serum; GSTA4, gene expression of glutathione S-transferase alpha 4; COX2, cyclooxygenase2; Cl5, claudin 5; HO1, Haemoxygenase1; LiverW, weight of liver; CRP, C-reactive protein; GCLM, glutamate-cysteine ligase modifier; MPO, myeloperoxidase; BodyW, body weight; Permeability, Cr51 permeability; ZO1, tight junction protein 1; IntestinL, intestine length; Calpro, Calprotectin; Food, food intake; Colon L, colon length; Water, water intake; MLCK, myosin light-chain kinase; JAMA, junctional adhesion molecule; UK2-4, unknown compounds; 4HPP, 3-(4-hydroxyphenyl)propionic acid; ba3, unknown bile acid