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Table 1 Characteristics of the study cohort

From: Alterations in the gut microbiome and metabolism with coronary artery disease severity

  Control
(n = 40)
SCAD
(n = 44)
UA
(n = 80)
MI
(n = 37)
P value
for trend
Age, years 55 (49, 62.25) 62.5 (52.5,68.8) 62.5 (57.3, 67.8) 63 (53.5, 72) 0.023b
Female§ 23 (57.5) 11 (25) 24 (30) 8 (21.6) 0.002abc
SBP, mmHg* 119.9 ± 10.8 130.8 ± 15.5 131.1 ± 17.7 126.5 ± 16.5 0.002abc
BMI, kg/m2* 24.2 ± 2.9 25.1 ± 3.3 26.7 ± 2.9 26.1 ± 3.8 < 0.001bc
Waistline, cm* 83.3 ± 10.2 90.1 ± 7.8 93.9 ± 8.7 93.6 ± 9.7 < 0.001abc
Current smoker§ 6 (15) 25 (56.8) 43 (53.8) 22 (59.5) < 0.001abc
Drinking history§ 6 (15) 21 (47.7) 38 (47.5) 22 (59.5) < 0.001abc
No. of stenosed vessels§      0.126
 NA NA 3 (6.8) 5 (6.3) 0 (0)  
 1 NA 13 (29.5) 26 (32.5) 5 (13.5)  
 2 NA 11 (25) 15 (18.8) 13 (35.1)  
 3 NA 17 (38.6) 34 (42.5) 19 (51.4)  
Gensini score NA 35.25 (24, 65.5) 44.25 (33, 60) 62.5 (47, 74.5) < 0.001de
Medication
 Statins§ 2 (5) 13 (29.5) 28 (35) 11 (29.7) 0.005abc
 Antihypertensive drugs§ 8 (20) 28 (63.6) 49 (61.3) 23 (62.2) < 0.001abc
 Oral antidiabetic drugs§ 2 (5) 12 (27.3) 15 (18.8) 12 (32.4) 0.014
Laboratory data
 TG, mmol/l 1.3 (0.86, 1.87) 1.25 (1, 1.6) 1.6 (1.1, 1.9) 1.3 (1.1, 2.1) 0.113
 TC, mmol/l 4.7 (4, 5.3) 3.7 (3.2, 4.6) 3.8 (3.3, 4.5) 4 (3.3, 4.7) 0.001abc
 HDL-C, mmol/l 1.1 (0.9, 1.4) 1 (0.8, 1.2) 0.9 (0.8, 1.1) 0.9 (0.8, 1.1) < 0.001abc
 LDL-C, mmol/l 2.8 (2.2, 3.2) 2.1 (1.7, 2.7) 2.2 (1.7, 2.7) 2.3 (1.6, 2.8) 0.013b
 FBG, mmol/l 6.2 (5.3, 7.9) 7.05 (5.9, 8.4) 6.4 (5.4, 7.9) 7.9 (6.2, 10.2) 0.019 c
 BUN, mmol/l 4.9 (4.3, 5.9) 5.9 (4.9, 6.8) 6.2 (4.9, 7.3) 5.7 (5, 7) 0.006bc
 CR, μmol/l 68.5 (61.2,79.8) 78.5 (67.3,92.8) 81.5 (68.25, 90) 79 (70.5, 89.5) 0.01bc
 cTnI, μg/l 0 0.005 (0, 0.02) 0.003 (0, 0.014) 0.08 (0.06, 1.1) < 0.001abcde
 hs-CRP, mg/l 0.7 (0.4, 1.2) 1.3 (0.6, 3.2) 1.9 (0.8, 2.9) 3.8 (2, 19.4) < 0.001bcde
 TNF-α, pg/mL 11.4 (3.1, 21.9) 25.9(15.2, 64.2) 22.6 (15.8, 38.9) 18.8 (14.3, 23.4) < 0.001abc
  1. median (IQR), *mean ± SD, §n (%)
  2. Continuous, normally distributed variables among the four groups were analysed by a one-way analysis of variance. The Kruskal-Wallis H-test was applied for data of this type that were not normally distributed. Continuous, normally distributed variables between two groups were analysed by Student’s t-test. The Mann-Whitney U test was applied for data of this type that were not normally distributed. Categorical variables were compared by the χ2 test. N/A not available. Drinking history is defined as patients who consumed ≥ 50 g of alcohol per day. aP < 0.05 for equality between SCAD vs. control. bP < 0.05 for equality between UA vs. control. cP < 0.05 for equality between MI vs. control. dP < 0.05 for equality between SCAD vs. MI. eP < 0.05 for equality between UA vs. MI.