Fig. 1

Identification of the major serum metabolite modules associated with the onset and development of CAD. a Spearman correlations between serum metabolite modules and major CAD phenotypes. b Spearman correlations between serum metabolite modules and major CAD risk factor indicators. c The box plot shows that the serum metabolite modules significantly changed between different groups according to the Wilcoxon rank sum test. The names of the metabolite clusters comprising the CAD-positive and CAD-negative metabotypes are highlighted in red and blue, respectively. In a and b, the colour represents positive (red) or negative (blue) correlations, and FDRs are denoted as follows: *FDR < 0.05, **FDR < 0.01. In c, the asterisk represents P values < 0.05 by the Wilcoxon rank sum test, boxes represent the inter-quartile ranges, and lines inside the boxes denote medians. PE phosphatidylethanolamine, PC phosphatidylcholine, GP glycerophospholipids, SBP systolic blood pressure, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, FBG fasting blood glucose, hs-CRP high-sensitivity C-reactive protein, IL-6 interleukin 6, TNF-α tumour necrosis factor-α