Fig. 3
From: Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis
Changes in the oral microbiome during chemotherapy and in relation to the development of oral mucositis. a Bacterial and fungal microbiome diversity in control and cancer subjects. Salivary bacterial diversity decreased at visit 3 compared to baseline and also the linear change (L) in diversity was significant. Decreased salivary bacterial diversity was also seen at the visit with the highest OMAS. Mucosal bacterial diversity increased at V2, while no changes were seen in salivary fungal communities. b Variables significantly correlated with the change in salivary bacterial diversity at each visit when compared to baseline. Data represent Spearman correlation coefficients with p values in parenthesis. Colored cells show correlations significant after adjustment for multiple comparisons via the FDR method. c Changes in community structure as measured by the ThetaYC distance from baseline (V1) to each visit. Black data points indicate changes in control subjects and color data points indicate cancer subjects. ** indicates a p value < 0.01 when comparing to control subjects via Mann-Whitney Rank tests. d Variables significantly correlated with changes in salivary and mucosal bacterial community structure (1-ThetaYC distance from baseline to each visit). Data represent Spearman correlation coefficients with p values in parenthesis. Colored cells show correlations significant after adjustment for multiple comparisons via the FDR method