Fig. 2

Fecal microbiome diversity differs in ICD compared with controls. Transcript abundances summarized by organism at the genus level were used to calculate Shannon (a) and Simpson (b) diversity measures. c PCA plot of control (red) and ICD (blue) organism metatranscriptome profiles. d The heatmap shows the pairwise distances between every pair of whole metatranscriptomes (including pairs of self against self). The darkness of the blue color in the heatmap indicates the Euclidean distance of the variance-stabilized count data from dark blue (smallest distance) to white (largest distance) between each pair of samples. Samples were clustered hierarchically. The dendrograms show the distances between samples with larger branch lengths indicating greater distances