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Table 3 Clinical characteristics of the subjects, grouped by residence location, at baseline

From: Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity

Characteristics

Young-healthy

Community

Long-stay

p b

Intervention

Placebo

p a

Intervention

Placebo

p a

Intervention

Placebo

p a

n

21

8

 

20

8

 

17

5

  

Sex (#male:female)

6:15

7:1

0.01

7:13

3:5

1.00

7:10

2:3

1.00

0.808

Age (years)

41.9 (14.5)

33.1 (13.2)

0.09

69.5 (4.9)

74.9 (7.5)

0.07

83.4 (7.6)

85 (7.6)

0.84

< 0.001

BMI (kg/cm2)

24.7 (5.0)

25.7 (3.5)

0.31

26.2 (4.3)

25.5 (1.4)

0.76

27.3 (6.2)

28.8 (7.7)

0.82

0.157

Weight (kg)

70.6 (13.5)

80.4 (10.6)

0.06

74.7 (14.9)

66.2 (8.8)

0.13

80 (28.1)

90.7 (28.5)

0.46

0.665

Charlson comorbidity

ND

ND

ND

0 (0)

0.1 (0.4)

0.13

2 (1.3)

3 (3.0)

0.75

< 0.001

Barthel score

ND

ND

ND

20 (0)

19.9 (0.4)

0.13

6.6 (5.5)

5 (3.5)

0.72

< 0.001

ALP (IU/L)

73.8 (26.0)

90.5 (24.6)

0.10

80.8 (16.6)

74.4 (17.7)

0.41

106.2 (28.9)

101.5 (39.3)

0.79

0.002

ALT (IU/L)

25.1 (12.6)

26.5 (5.9)

0.29

23.8 (10.9)

24 (7.7)

0.58

13.9 (7.2)

12.5 (4.5)

0.86

< 0.001

AST (IU/L)

25.2 (4.5)

28.8 (6.8)

0.19

27.3 (7.1)

31.2 (13.6)

0.94

19 (4.9)

16 (3.2)

0.33

< 0.001

Bilirubin (μmol/L)

14.1 (10.6)

10.9 (5.0)

0.45

12.1 (5.8)

11.1 (4.5)

0.75

6.5 (2.0)

7 (2.4)

0.65

< 0.001

Total cholesterol (mmol/L)

5.5 (0.7)

5.7 (1.1)

0.90

5.5 (1.2)

5.1 (1.2)

0.49

4.5 (0.9)

4.8 (1.9)

0.87

0.004

HDL-cholesterol (mmol/L)

1.5 (0.3)

1.4 (0.3)

0.15

1.6 (0.3)

1.8 (1.2)

0.30

1.2 (0.3)

1.1 (0.2)

0.64

0.001

LDL-cholesterol (mmol/L)

3.4 (0.6)

3.6 (0.9)

0.59

3.5 (1.2)

2.9 (0.8)

0.29

2.6 (0.8)

2 (0.8)

0.40

0.004

Triglycerides (mmol/L)

1.3 (0.5)

1.5 (0.6)

0.59

1.2 (0.4)

1.3 (0.3)

0.33

1.7 (0.8)

2.8 (1.9)

0.23

0.030

Fasting glucose (mmol/L)

4.5 (0.6)

4.5 (0.5)

0.48

5.2 (0.7)

5 (0.6)

0.49

6.1 (1.6)

7.7 (2.8)

0.22

< 0.001

Creatinine (μmol/L)

71.5 (12.2)

80.9 (15.8)

0.07

70.1 (14.4)

76.1 (23.3)

0.52

91 (48.0)

104.5 (38.9)

0.59

0.068

Ferritin (μg/L)

73.8 (48.5)

98.1 (64.5)

0.39

102.6 (63.2)

107.6 (53.7)

0.61

80.9 (70.7)

40.3 (10.1)

0.79

0.094

TSH (mIU/L)

1.9 (0.8)

1.6 (0.3)

0.39

2.5 (1.3)

2.4 (1.3)

0.92

1.7 (0.6)

1.1 (1.0)

0.30

0.037

Urea (mmol/L)

5.4 (1.1)

5.5 (1.2)

0.96

5.7 (1.4)

5.5 (1.0)

0.58

8.7 (3.6)

11.6 (4.1)

0.11

< 0.001

Vitamin B12 (pg/mL)

265.1 (159.3)

318.8 (120.6)

0.12

332.6 (153.3)

303.4 (93.4)

0.79

234.2 (119.5)

195.7 (46.6)

0.63

0.009

White blood cell count

6 (1.6)

6.1 (1.4)

0.79

5.5 (1.1)

6.2 (1.7)

0.47

7.3 (2.6)

6.9 (0.7)

0.90

0.042

HFD index

0.5 (0.1)

0.4 (0.1)

0.031

0.4 (0.1)

0.4 (0.1)

0.409

0.3 (0.1)

0.4 (0.1)

0.179

< 0.001

  1. Data presented as mean (SD)
  2. ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate transaminase, TSH thyroid-stimulating hormone, HFD healthy food diversity, ND not done
  3. aMann-Whitney U test for two treatment groups except Fisher’s test for sex ratio
  4. bKruskal-Wallis test for three residence location groups
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Microbiome

ISSN: 2049-2618

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