Fig. 3

Systemic microbial translocation and distinct B cell repertoire profiles in autoantibody induction in HIV+ subjects. a Plasma LPS and sCD14 level were analyzed at baseline (D0) from the three study groups. b Sorted B cells on D14 post-vaccination were analyzed by BCR repertoire, the clonal diversity of B cells from HIV+ groups shown by the Hill diversity index (qD, y axis). The median diversity score over all resampling realizations and 95% percentile were plotted as a line and a shaded background. All samples were randomly sampled to 4000 sequences for each resampling realization to correct for variations in sequencing depth. c PCoA plot of Bray-Curtis dissimilarity comparing baseline plasma bacterial 16s microbiome communities. d The average relative abundance of each bacteria at the phylum level. e The average relative abundance of each bacteria at the genus level