CAMISIM: simulating metagenomes and microbial communities

Microbiome

Table 1 Properties of popular metagenome sequence simulators

Software	De novo	Profile	Multi	Strains	Non-Illumina data	Licensed	Updated
MetaSim [62]	✓	X	X	✓	454	P, AU	03/2009
iMESS [63]	✓	X	X	X	454	–	07/2014
BBMap [64]	✓	X	X	X	–	LBL	01/2019
NeSSM [42]	✓	✓	X	X	454	AU	07/2013
BEAR [43]	✓	✓	X	X	–	AU	02/2017
FASTQSim [44]	✓	✓	X	X	SOLiD, IonTorrent, PacBio	GPL	05/2015
Grinder [45]	✓	✓	✓	X	Sanger, 454	GPL	04/2016
CAMISIM	✓	✓	✓	✓	PacBio, ONT, …	Apache 2.0	01/2019

Abbreviations: P, proprietary software; AU, academic use only; LBL, Lawrence Berkeley Lab
The table shows if an abundance profile can be generated by the simulator de novo and if an existing profile of a microbial community can be used as input. Further inspected features are the ability to simulate multi-sample data sets, strains, and non-Illumina data (e.g., long reads). Lastly, the table states if and how a software is licensed, and the date it was last recently updated

ISSN: 2049-2618