Table 2 Comparison of asthma characteristics in overall cohort and among asthma phenotypic clusters (APC)
From: Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas
Variable | All (n = 163) | APC1 (n = 51) | APC2 (n = 63) | APC3 (n = 49) | P value |
|---|---|---|---|---|---|
Sex, % malea | 52.6 | 29.5 | 65.1 | 63.2 | < 0.001 |
Age, years (SE)a | 11.0 (0.3) | 12.7 (0.5) | 9.1 (0.3) | 11.6 (0.5) | < 0.001 |
Age of onset of asthma symptoms, years (SE) | 4.1 (0.2) | 4.9 (0.5) | 3.4 (0.3) | 4.3 (0.5) | 0.0046 |
BMI percentile (SE)a | 72 (2.2) | 81.3 (3.0) | 81.1 (2.7) | 53.7 (4.5) | < 0.001 |
Pre-bronchodilator FEV1, % predicted (SE) | 85.4 (1.4) | 88 (2.0) | 84.8 (2.6) | 83.2 (2.6) | 0.401 |
FEV1 change with bronchodilator (SE) | 5.8 (0.4) | 10.3 (1.6) | 8.6 (1.6) | 14.4 (4.4) | 0.299 |
Post-bronchodilator FEV1, % predicted (SE) | 99.2 (6.0) | 96 (2.2) | 93.6 (2.9) | 109.2 (18.6) | 0.518 |
NAEPP Severity | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | 0.3 |
ACT scorea | 20.4 (0.3) | 16.2 (0.5) | 21.6 (0.3) | 23.1 (0.4) | < 0.001 |
ITGc—composite score (IQR)a | 68.9 (54.2, 86.5) | 51.2 (41.7, 57.3) | 71.3 (64.1, 79.2) | 84.2 (72.9, 95.8) | < 0.001 |
Blood eosinophil, % (IQR)a | 5.8 (2.25, 5.75) | 4.5 (1.8, 6.3) | 8.9 (5.3, 11.7) | 3.2 (1.2, 4.7) | < 0.001 |
Total serum IgE (IQR) | 545 (99, 710) | 579 (97, 751) | 675 (139, 912) | 330 (75, 368) | 0.013 |
Positive skin allergen tests, % | 73 | 35 | 46 | 25 | 0.006 |
Beta agonist use, % | 27 | 11 | 8 | 11 | 0.471 |
Inhaled steroid use, % | 54.6 | 17.2 | 23.9 | 13.5 | 0.342 |