Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas

Microbiome

Table 1 Varimax rotation of 11 asthma-relevant variables

Variable	Component
Variable	1	2	3	4
ACT score^a	0.798
ITGc—composite score^a	0.984
ITGf—functional limitations score	0.864
ITGd—daytime symptoms score	0.848
ITGn—nighttime symptoms score	0.842
Post-bronchodilator FEV₁ (% predicted)				0.967
Post-bronchodilator FEV₁/FVC (% predicted)			0.765
FEV₁ change with bronchodilator			0.784
Age, years^a		− 0.551
Blood eosinophil, %^a		0.761
Total serum IgE, IU/mL		0.741

Extraction method: principal component analysis. Rotation method: varimax with Kaiser normalization. Bartlett’s test of sphericity < 0.001. KMO measure of sampling adequacy: 0.471. ACT asthma control test, ITG Integrated Therapeutics Group’s Child Asthma Short Form, FEV forced expiratory volume, FEF forced expiratory flow, IgE immunoglobulin E. ^aVariable used in cluster analysis.

ISSN: 2049-2618