Fig. 5

a The first 10 nearest independent healthy neighbors. This plot shows the restoration of the microbiome in responders to FMT, as the distances were very similar between samples from healthy subjects and those with successful FMT. This also shows failed restoration of the microbiome in the non-responder patient, as the distances were very different between the samples from failed patient and from the healthy subjects. b Plot of the log10 outlier percentile in patients who received FMT. The dashed line represents an outlier percentile of 0.05. When using k = 5% of the population, non-responder patient was considered as outlier. Using large neighborhood sizes classified 1 responder patient as outlier. c Patient stability as measured by self-similarity over time. Plot of the distance of a day to the corresponding previous day using Unweighted UniFrac distance. The figure shows stability between two consecutive samples of the fecal microbiome in healthy controls and in responder patients among days whereas the non-responder patient showed instability between two consecutive samples