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Table 1 Proportions of bacterial taxa (with > 0.1% in at least one of the treatments) significantly influenced by dietary treatments within treatment groups (FDR-adjusted P value < 0.1). Significant values are set in italics

From: Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics

Treatment

     
 

Taxonomic group

Baseline

Treatment

P value

Q value

(FDR adjusted)

IVS-1

Phylum

    
 

 Actinobacteria

9.106 ± 5.25

15.422 ± 5.98

0.0072

0.0316

 

Genus

    
 

Bifidobacterium

7.605 ± 7.41

14.565 ± 6.92

0.0138

0.0420

 

OTUsa

    
 

 OTU_1 (B. adolescentis)

1.199 ± 4.24

3.403 ± 5.08*

0.0010

0.0176

 

 OTU_167 (B. animalis subsp. lactis)

0.001 ± 0.00

0.001 ± 0.00

1.0000

1.0000

 

 OTU_7 (B. adolescentis or ruminantium)

0.817 ± 2.24

1.916 ± 4.33

0.0291

0.0516

Bb 12

Phylum

    
 

 Actinobacteria

10.660 ± 5.17

11.886 ± 7.68

0.9051

0.9540

 

Genus

    
 

Bifidobacterium

8.796 ± 5.70

9.450 ± 8.39

0.8782

0.9514

 

OTUsa

    
 

 OTU_1 (B. adolescentis)

1.237 ± 2.46

1.160 ± 1.62

0.7787

0.8814

 

 OTU_167 (B. animalis subsp. lactis)

0.034 ± 0.04

0.055 ± 0.05

0.0073

0.0316

IVS-1 GOS

Phylum

    
 

 Actinobacteria

8.129 ± 4.79

15.780 ± 7.11

0.0015

0.0176

 

Genus

    
 

Bifidobacterium

5.959 ± 5.88

14.650 ± 7.44

0.0039

0.0253

 

Anearotrunctus

0.048 ± 0.09

0.010 ± 0.01

0.0236

0.0511

 

Roseburia

3.379 ± 1.64

1.825 ± 1.15

0.0018

0.0176

 

OTUsa

    
 

 OTU_1 (B. adolescentis)

2.476 ± 4.49

7.344 ± 7.00*

0.0176

0.0476

 

 OTU_167 (B. animalis subsp. lactis)

0.001 ± 0.00

0.003 ± 0.01

1.0000

1.0000

 

 OTU_102 (Lachnospiracea incertae sedis)

0.352 ± 0.49

0.070 ± 0.16

0.0100

0.0390

 

 OTU_152 (Alistipes)

0.176 ± 0.36

0.013 ± 0.05

0.0463

0.0722

Bb 12 GOS

Phylum

    
 

 Actinobacteria

11.665 ± 5.90

17.034 ± 6.51

0.0279

0.0516

 

Genus

    
 

Bifidobacterium

8.862 ± 6.15

15.86 ± 7.97

0.0140

0.0420

 

Anaerovorax

0.295 ± 0.09

0.18 ± 0.09

0.0283

0.0516

 

OTUsa

    
 

 OTU_1 (B. adolescentis)

3.138 ± 4.53

6.797 ± 9.61

0.0812

0.1131

 

 OTU_167 (B. animalis subsp. lactis)

0.003 ± 0.001

0.112 ± 0.18

0.0006

0.0176

 

 OTU_156 (Clostridium XI)

0.151 ± 0.20

0.071 ± 0.21

0.0345

0.0585

GOS

Phylum

    
 

 Actinobacteria

13.923 ± 8.98

18.067 ± 9.78

0.0468

0.0722

 

Genus

    
 

Bifidobacterium

11.329 ± 10.48

17.358 ± 11.41

0.0686

0.0991

 

Bacteroides

5.794 ± 4.43

2.854 ± 4.11

0.0121

0.0420

 

OTUsa

    
 

 OTU_1 (B. adolescentis)

3.793 ± 7.47

6.645 ± 8.83

0.1221

0.1587

 

 OTU_167 (B. animalis subsp. lactis)

0.000 ± 0.00

0.203 ± 0.85

0.4504

0.5489

Lactose

Phylum

    
 

 Actinobacteria

10.471 ± 6.75

14.502 ± 6.89

0.0529

0.0794

 

Genus

    
 

Bifidobacterium

7.895 ± 8.10

12.008 ± 8.02

0.0917

0.1233

 

OTUsa

    
 

 OTU_1 (B. adolescentis)

1.241 ± 1.93

2.557 ± 4.11

0.6562

0.7755

 

 OTU_167 (B. animalis subsp. lactis)

0.000 ± 0.00

0.037 ± 0.14

0.7910

0.8814

 

 OTU_315 (Coprobacillus)

0.100 ± 0.09

0.062 ± 0.06

0.0023

0.0179

 

 OTU_43 (Ruminococcus2)

0.562 ± 0.75

0.272 ± 0.63

0.0051

0.0284

 

 OTU_180 (Bacteroides)

0.041 ± 0.17

0.127 ± 0.40

0.0183

0.0476

  1. aIf the strain could not be assigned to a type strain (< 97% homology), RDP Classifier was used to determine the most likely genus (80% cutoff)
  2. *Significant difference between the two treatment groups for OTU_1