Skip to main content
Fig. 4 | Microbiome

Fig. 4

From: Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats

Fig. 4

Alteration of fecal microbiome is closely associated with SLCFA generation in NMS rats (n = 8/group). a Principal coordinate analysis (PCoA) of microbial beta-diversity between both groups. The first two principal coordinates (PCs) respectively explain 36.36% and 17.35% of variation in the dataset. b The relative abundances of dominant genera in fecal microbiota. c The spearman’s correlation between changed fecal species and fecal C15:0, C17:0, C14:0. Only species correlated with at least one SLCFA with adjusted p < 0.05 are shown in the heatmap. d The relative abundances of fatty acid biosynthesis, elongation and degradation based on KO module analysis. e The relative abundances of genes encoding enzymes for SLCFA synthesis. f The relative abundances of genes encoding enzymes for β-oxidation. Differential abundance of taxa and KOs were evaluated by two-tailed Wilcoxon rank-sum test, and significance is defined as *p < 0.05; **p < 0.01; ***p < 0.005. Abbreviation: Acaca, acetyl-CoA carboxylase; Fas, fatty acid synthase (bacteria type); FabD, Malonyl CoA-acyl carrier protein; FabF, 3-oxoacyl-[acyl-carrier-protein] synthase II; FabG, 3-oxoacyl-[acyl-carrier protein] reductase; FabZ, 3-hydroxyacyl-[acyl-carrier- protein] dehydratase; FabI, enoyl-[acyl-carrier protein] reductase I; TesA, acyl-CoA thioesterase I; YciA, acyl-CoA thioesterase; FadL, long-chain fatty acid transport protein; FadD, long-chain acyl-CoA synthetase; FadE, acyl-CoA dehydrogenase; FadB, 3-hydroxybutyryl-CoA dehydrogenase; FadH, 2,4-dienoyl- CoA reductase; FadA, acetyl-CoA acyltransferase

Back to article page
\