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Fig. 3 | Microbiome

Fig. 3

From: Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats

Fig. 3

C17:0 and C18:0 dose-dependently stimulate colonic motility ex vivo and in vivo, and such SLCFA-induced muscle contraction can be attenuated by TLR4 inhibitor C34. a, b The effects of C17:0 and C18:0 on the contraction of circular muscles of isolated colon segments through an organ bath system. The amplitude of contractions was expressed as force/area (g/mm2). c The effects of selective GPR40 antagonist DC260126 (DC) on C18:0-induced colonic muscle contraction. d, e The effects of C17:0 and C18:0 on the accumulation of fecal pellet output within 60 min in normal rats (n = 8/group). f The accumulated amounts of SLCFAs per gram of colonic contents in SLCFA-treated and vehicle rats. Statistical differences among individual groups were evaluated using One-way ANOVA, and significance is defined as *p < 0.05; **p < 0.01; ***p < 0.005

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