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Fig. 1 | Microbiome

Fig. 1

From: Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

Fig. 1

Overview of genome-wide significant loci discovered in four recent GWAS studies [9,10,11,12]. For simplicity, only the regions harboring a coding gene are shown, and for Wang et al. [14], the list was further refined to genes implicated in previous mouse QTL studies and to additional loci identified by an improved method (shown in gray, Rühlemann et al. Gut microbes, 2017). So far, the only overlap found in the three studies is the SLIT3 locus, although two studies reported two SNPs not in linkage disequilibrium. The LCT locus was not significant in the initial analysis using an additive model, but analyzing functional SNPs in the recessive model identified a significant association for LCT in the Dutch cohort [15]

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