Fig. 4

Jax and Tac microbiota composition converges following FMT, including transfer of ASVs transferred by cohousing. a Heat map of percent relative abundance of ASVs in Jax and Tac mice before FMT, or 1 day after the third FMT from either vendor-matched fecal donor (self-FMT) or fecal donor from different vendor (cross-FMT). Each row represents an individual mouse. Each column represents a single ASV. Only ASVs with percent relative abundance of at least 1% in a minimum of two samples from the same vendor were included. Arrangement of ASVs was kept constant between all rows. Bottom row displays the phylum to which the ASV in the same column was assigned. b Principal coordinate analysis of female B6 Jax and Tac fecal microbiota composition using Bray-Curtis distance following either self-FMT (Jax to Jax, Tac to Tac) or cross-FMT (Tac to Jax, Jax to Tac). c Percent relative abundance of ASVs associated with prolonged graft survival in Jax and Tac mice either pre-FMT, or 1 or 15 days after the third self-FMT or cross-FMT. Each dot represents an individual mouse. *P < 0.05, ns = not significant