Cohort | Factor | Control | CRC | P value | Sample collection | Sequencing platform |
---|---|---|---|---|---|---|
Cohort C1 (American, 2016) | Sample size | 52 | 48 | NA | Prior to surgery and treatment | Sequencing Platform: Illumina Hiseq 2000/2500; Sequencing Target Depth: 5GB; read length: 100Â bp |
Age | 61.23(11.03) | 60.96(13.56) | 0.913 | |||
Gender | Male:37; Female:15 | Male:35; Female:13 | 1 | |||
BMI | 25.35(4.27) | 24.90(4.29) | 0.601 | |||
Cohort C2 (Austrian, 2014) | Sample size | 63 | 46 | NA | Not available | |
Age | 67.1(6.37) | 67.1(10.91) | 0.999 | |||
Gender | Male:37; Female:26 | Male:28; Female:18 | 0.978 | |||
BMI | 27.57(3.78) | 26.50(3.53) | 0.132 | |||
Cohort C3 (Chinese, 2015) | Sample size | 92 | 73 | NA | No antibiotics and no invasive medical intervention for 3Â months; no vegetarian diet; no history of cancer or inflammatory disease of intestine | |
Age | 58.51(7.55) | 65.90(10.61) | < 0.0001 | |||
Gender | Male:51; Female:41 | Male:47; Female:26 | 0.316 | |||
BMI | 23.87(3.31) | 24.07(3.18) | 0.697 | |||
Cohort C4 (German and French, 2014) | Sample size | 64 | 88 | NA | No previous colon or rectal surgery, colorectal cancer, inflammatory, or infectious injuries of the intestine; no need for need for emergency colonoscopy | |
Age | 58.75(12.96) | 68.44(12.22) | 0.007 | |||
Gender | Male:32; Female:32 | Male:53; Female:35 | 0.276 | |||
BMI | 24.72(3.19) | 25.89(4.29) | 0.056 |