The implausible “in vivo” role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota

Microbiome

Table 1 Concentrations of hydrogen peroxide and lactic acid produced by Lactobacillus spp. under different conditions and concentrations necessary to inactivate HIV and BV-associated bacteria

Conditions	H₂O₂ [mM]		Lactic acid [mM]
Culture medium under hypoxic conditions	Undetectable	[46]	160–250	[22, 47]
Aerated culture medium	3.34–4.39	[46]	45	[22]
Lactobacillus-dominated CVF under hypoxic conditions	Undetectable	[16]	110	[23]
Aerated Lactobacillus-dominated CVF	0.023	[16]	63	[23]
Inactivation of HIV in culture medium	5	[48]	33	[32]
Inactivation of BV-associated bacteria in culture medium	10	[23]	55–110	[23]
Inactivation of HIV in the presence of CVF	Undetermined		33–110	[32]
Inactivation of BV-associated bacteria in the presence of CVF	> 1000	[23]	55–110	[23]
Inactivation of Lactobacillus in culture medium	> 1000	[23]	> 1000	[23]

ISSN: 2049-2618