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Table 2 Gut scoring matrix (maximum 29)

From: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Feature Score Description
Colon
Crypt architecture 0 Normal
1 Irregular
2 Moderate crypt loss (10–50%)
3 Severe crypt loss (50–90%)
4 Small/medium ulcers (< 10 crypt widths)
5 Large ulcers (> 10 crypt widths)
Crypt abscesses 0 None
1 1–5
2 6–10
3 > 10
Crypt length (medial colon) 0 < 250 μm
1 250–300 μm
2 300–350 μm
3 350–400 μm
4 > 400 μm
Tissue damage 0 No damage
1 Discrete lesions
2 Mucosal erosions
3 Extensive mucosal damage
Inflammatory cell infiltration 0 Occasional infiltration
1 Increasing leukocytes in lamina propria
2 Confluence of leukocytes extending to submucosa
3 Transmural extension of inflammatory infiltrates
Lamina propria neutrophils (PMN) 0 0–5 PMNs/HPF
1 6–10 PMNs/HPF
2 11–20 PMNs/HPF
3 > 20 PMNs/HPF
Ileum
Inflammatory cell infiltration 0 Occasional infiltration
1 Increasing leukocytes in lamina propria
2 Confluence of leukocytes extending to submucosa
3 Transmural extension of inflammatory infiltrates
Lamina propria neutrophils (PMN) 0 0–5 PMNs/HPF
1 6–10 PMNs/HPF
2 11–20 PMNs/HPF
3 > 20 PMNs/HPF
Paneth cell 0 Normal: small, densely packed granules
1 Irregular: less granules
2 Abnormal: less granules, large vacuolar spaces