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Fig. 6 | Microbiome

Fig. 6

From: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Fig. 6

Therapeutic administration of interleukin-2 restores an immunoregulatory environment, reduces gut inflammation, and alters the core gut microbiome of NOD mice. NOD mice were treated with PBS or IL-2c weekly for 6 weeks. a Mean insulitis score from the pancreas sections. b Foxp3+ Treg proportions at the end of treatment in the spleen, mesenteric and pancreatic LN, and colon lamina propria. c Overall gut inflammation score. d CD45+ cell infiltration within the colon lamina propria. e Mean goblet cell area was calculated from PAS staining of five representative crypts. f Representative PAS-stained section of the colon. Data pooled from two experiments. g sPLS-DA multivariate analysis. Data pooled from three experiments. h Contribution plot showing genera contributing to component 1 of the sPLS-DA plot. FDRp indicates the adjusted p value of each genera between strains following PERMANOVA testing. See also Additional file 1: Figures S1 and S6

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