Fig. 6

The interaction network of bacterial genera and phage OTUs determined by SparCC. Nodes represent OTUs; round: pOTUs; hexagon: bacterial genera. Only bacterial genera and pOTUs with a high frequency (detected in more than 72.5 samples (50%)) were considered. The co-correlation/exclusion interactions between bacterial genera and pOTUs as well as between bacterial genera were calculated with SparCC. The size of each node is proportional to the number of samples. The width of the edges between nodes is proportional to the correlation values between the nodes, with blue and black indicating the positive and negative correlations, respectively. Only edges corresponding to correlations greater than 0.3 and a p value less than 0.01 are shown, and unconnected nodes were omitted. The network layout was calculated by the Cytoscape software using a circular layout. The names of pOTUs with a putative Enterobacteria host are marked as yellow, and those with a putative Escherichia host are marked as cyan; the nodes representing the bacterial genera enriched in the control group are filled in with red, while the nodes representing the pOTUs enriched in the T2D group are filled in with green. The detailed names of the bacterial genera and only the pOTUs marked with colors were shown on the left panel of the figure. The detailed names of other pOTUs were shown in Additional file 3, Table S6