TY - JOUR AU - Stanislawski, Maggie A. AU - Dabelea, Dana AU - Wagner, Brandie D. AU - Sontag, Marci K. AU - Lozupone, Catherine A. AU - Eggesbø, Merete PY - 2017 DA - 2017/09/04 TI - Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants JO - Microbiome SP - 113 VL - 5 IS - 1 AB - Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mothers at the time of delivery and their infants in early life. In this study, we performed 16S rRNA gene sequencing on gut microbiota samples from 169 women 4 days after delivery and from the 844 samples of their infants at six timepoints during the first 2 years of life. We categorized the women (1) according to pre-pregnancy body mass index into overweight/obese (OW/OB, BMI ≥ 25) or non-overweight/obese (BMI < 25) and (2) into excessive and non-excessive GWG in the subset of mothers of full-term singleton infants (N = 116). We compared alpha diversity and taxonomic composition of the maternal and infant samples by exposure groups. We also compared taxonomic similarity between maternal and infant gut microbiota. SN - 2049-2618 UR - https://doi.org/10.1186/s40168-017-0332-0 DO - 10.1186/s40168-017-0332-0 ID - Stanislawski2017 ER -