Table 2 Significant Gene Ontology and pathways annotations among FusoSecretome inferred human interactors
From: Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
Annotation source | Annotation ID | Annotation name | Corrected P-value |
|---|---|---|---|
Biological process | Â | ||
|  | GO:0006415 | Translational termination | 7.57 × 10−41 |
GO:0006414 | Translational elongation | 2.65 × 10−34 | |
GO:0006457 | Protein folding | 2.51 × 10−29 | |
GO:0006413 | Translational initiation | 6.63 × 10−27 | |
GO:0072376 | Protein activation cascade | 1.17 × 10−25 | |
GO:0051604 | Protein maturation | 5.45 × 10−23 | |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 1.93 × 10−22 | |
GO:0006956 | Complement activation | 3.62 × 10−21 | |
GO:0002697 | Regulation of immune effector process | 4.03 × 10−18 | |
GO:0030449 | Regulation of complement activation | 4.10 × 10−18 | |
Cellular component | Â | ||
|  | GO:0005840 | Ribosome | 9.81 × 10−37 |
GO:0022626 | Cytosolic ribosome | 2.76 × 10−23 | |
GO:0005912 | Adherens junction | 4.15 × 10−22 | |
GO:0098552 | Side of membrane | 2.46 × 10−18 | |
GO:0030055 | Cell-substrate junction | 2.85 × 10−17 | |
GO:0072562 | Blood microparticle | 9.20 × 10−17 | |
GO:0005761 | Mitochondrial ribosome | 4.28 × 10−12 | |
GO:0019897 | Extrinsic component of plasma membrane | 2.35 × 10−09 | |
GO:0005911 | Cell-cell junction | 4.54 × 10−08 | |
GO:0031012 | Extracellular matrix | 3.91 × 10−07 | |
KEGG | Â | ||
|  | KEGG:03010 | Ribosome | 4.34 × 10−39 |
KEGG:04610 | Complement and coagulation cascades | 2.28 × 10−22 | |
KEGG:04514 | Cell adhesion molecules (CAMs) | 2.88 × 10−09 | |
KEGG:04141 | Protein processing in endoplasmic reticulum | 2.03 × 10−08 | |
KEGG:04660 | T cell receptor signaling pathway | 1.33 × 10−07 | |
KEGG:05150 | Staphylococcus aureus infection | 1.78 × 10−06 | |
KEGG:04380 | Osteoclast differentiation | 7.25 × 10−06 | |
KEGG:05203 | Viral carcinogenesis | 8.21 × 10−06 | |
KEGG:05169 | Epstein-Barr virus infection | 1.11 × 10−05 | |
KEGG:05164 | Influenza A | 1.77 × 10−05 | |
Reactome | Â | ||
|  | REAC:1,592,389 | Activation of Matrix Metalloproteinases | 4.77 × 10−28 |
REAC:192,823 | Viral mRNA Translation | 2.14 × 10−19 | |
REAC:156,902 | Peptide chain elongation | 2.14 × 10−19 | |
REAC:975,956 | Nonsense Mediated Decay independent of the Exon Junction Complex | 1.83 × 10−17 | |
REAC:977,606 | Regulation of Complement cascade | 5.13 × 10−16 | |
REAC:202,733 | Cell surface interactions at the vascular wall | 7.22 × 10−16 | |
REAC:5,368,287 | Mitochondrial translation | 3.61 × 10−14 | |
REAC:3,371,453 | Regulation of HSF1-mediated heat shock response | 3.92 × 10−14 | |
REAC:3,371,599 | Defective HLCS causes multiple carboxylase deficiency | 1.33 × 10−08 | |
REAC:420,597 | Nectin/Necl trans heterodimerization | 1.33 × 10−08 | |