Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins

Microbiome

Table 1 Enrichment of Pfam domains in the FusoSecretome compared to non-secreted proteins

Pfam domain	Pfam clan^a	Function	VFDB^b	Human^c	FusoSecretome^d	non-secreted^e	Corrected P value^f
MORN repeat variant	MORN repeat	Invasion	–	–	16	2	2.17 × 10⁻¹²
Autotransporter beta-domain	Outer membrane beta-barrel protein superfamily	Adhesion	✓	–	9	0	2.4 × 10⁻⁷
Haemolysin secretion/activation protein ShlB/FhaC/HecB	Outer membrane beta-barrel protein superfamily	Secretion	✓	–	5	0	0.002
TonB-dependent Receptor Plug Domain	Ubiquitin superfamily	Transport	✓	–	5	0	0.002
TonB dependent receptor	Outer membrane beta-barrel protein superfamily	Transport	✓	–	4	0	0.011
Surface antigen variable number repeat	POTRA domain superfamily	Folding	–	–	4	0	0.011
YadA-like C-terminal region	Pilus subunit	Adhesion	✓	–	4	0	0.011
Haemagluttinin repeat	Pectate lyase-like beta helix	Adhesion	✓	–	4	0	0.011
Bacterial extracellular solute-binding proteins, family 5 Middle	Periplasmic binding protein clan	Transport	–	–	5	4	0.082
Coiled stalk of trimeric autotransporter adhesion	–	Adhesion	✓	–	3	0	0.09
Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	Thiamin diphosphate-binding superfamily	Metabolism	–	–	3	0	0.09
TPR repeat	Tetratrico peptide repeat superfamily	Protein binding	✓	✓	6	8	0.094

^aA clan is defined as a collection of related Pfam entries sharing sequence or structural similarity
^bPfam entry detected in at least one protein sequence stored in the database of known bacterial virulence factors
^cPfam entry detected in at least one human protein sequence
^dNumber of occurrences in the FusoSecretome
^eNumber of occurrences in non-secreted proteins
^fPfam domain matches with a corrected P value <0.1

ISSN: 2049-2618