From: The metabolic footprint of the airway bacterial community in cystic fibrosis
Parameter(s) | CF (n = 16) | Control (n = 8) | P value |
---|---|---|---|
Age, years | 31.0 (25.5, 36.0) | 33.5 (26.5, 46.5) | NS* |
Sex (male:female) | 10:6 | 0:8 | 0.006†|
Race (EA:AA:other) | 15:1:0 | 1:7:0 | 0.001†|
Antibiotic use (yes:no) | 14:2 | 0:8 | NA§ |
Serum IgE, U/mL | 77.5 (29.5, 119.5) | 72.5 (23.0, 201.0) | NS |
Absolute blood eosinophils | 0.16 (0.11, 0.26) | 0.11 (0.06, 0.18) | NS |
FVC, % predicted | 84.0 (59.5, 98.5) | 108.0 (99.0, 113.5) | 0.003 |
FEV1, % predicted | 72.5 (55.5, 87.5) | 106.0 (95.5, 112.0) | 0.001 |
Neutrophils, % of total WBC | 71.5 (63.0, 76.0) | 58.5 (49.0, 62.5) | 0.007 |
Absolute blood neutrophils | 6.29 (3.77, 8.73) | 2.77 (1.89, 4.22) | 0.005 |
CF genotype (for full details, see Additional file 1) | |||
 Processing defect (F508del homo/heterozygous) | 11 | ND⌘ | NA |
 Gating mutation (G551D) | 3 | ND | NA |
 Non-sense mutation (R1158X, G542X) | 2 | ND | NA |