Skip to main content
Fig. 6 | Microbiome

Fig. 6

From: Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy

Fig. 6

Differential effects of the components in the HRZ cocktail on the intestinal microbiota. a Nine groups of mice with 3–4 animals in each group were employed. One group was left untreated as the naïve age-matched control. Seven of the groups were each treated with one or a combination of H (Isoniazid), R (Rifampin), and/or Z (Pyrazinamide) as indicated and separated by a ‘/’. The last group was treated with a cocktail of vancomycin, ampicillin, neomycin, and metronidazole (VANM). b Bacterial community diversity of all the samples in each group was estimated using alpha diversity indices Chao1 (left) and Shannon (right). Error bars indicate maximum and minimum values. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, Welch’s t test. Blue and pink asterisks indicate significance in comparison to Naïve and VANM, respectively. c Principal coordinate (PC) analysis of unweighted UniFrac distances of sequences from all nine groups. d Average relative abundance of bacterial families in each group identified from the sequenced data. The bacterial families are grouped under their respective phylum and class in the color key. e Heat map showing the average species level abundance. Data shown are filtered for an overall relative variance >10 and depicted as described in Fig. 1c except along the x-axis which show the different treatment groups. Naïve, VANM, HRZ, n = 3; remaining groups n = 4

Back to article page