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Fig. 3 | Microbiome

Fig. 3

From: Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy

Fig. 3

ATT causes a rapid and persistent alteration in the composition of the intestinal microbiota. a Average relative abundance of bacterial families in each group and experimental time point identified from the sequenced data of the stool samples. Time points are indicated along the x-axis and arranged by the experimental groups. The bacterial families are grouped under their respective phylum and class in the color key. b Heat map showing the average species level abundance. Data are filtered for overall relative variance >5 and clustered as described in Fig. 1c. c, d LEfSe analyses depicting genera that are differentially abundant between the naïve and TB + HRZ groups (c) and TB and TB + HRZ groups (d). Analyses were performed on data from W4 to W20 time points (see “Methods”). Taxa significantly enriched in naïve, TB, and TB + HRZ groups are shown with blue, red, and orange bars, respectively. Data are filtered for p < 0.01 and linear discriminant analysis (LDA) score >2. n = 4–5 except TB group W20 time point where n = 3

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