Skip to main content
Fig. 1 | Microbiome

Fig. 1

From: Uncovering the trimethylamine-producing bacteria of the human gut microbiota

Fig. 1

Results of the multiparametric genome-screening approach for the genes cutC (a) and cntA (b). Obtained unique proteins are depicted along the horizontal axis where they are sorted according to their similarity to the constructed hidden Markov chain models (HMM) represented by the primary vertical axis. The secondary vertical axis depicts both the phylogenetic distance to the top-scoring sequences (triangles) and synteny (diamonds) to the corresponding partner genes cutD and cntB. Taxonomic affiliations of sequences are indicated by the color code. Asterisks indicate sequences lacking conserved amino acid residues. Cutoffs set to discriminate true cutC (HMM score of 906.4) and cntA (HMM score of 440.6) genes are illustrated in the respective plots. For cntA, phylogeny was applied as an additional filtering step (see text). Final databases for cutC and cntA contained 1114 (454 unique proteins) and 6772 (491 unique proteins) candidate genes, respectively. CntA reference sequences derived from Acinetobacter baumannii (Ab) and Escherichia coli (Ec; previously termed yeaW) are highlighted by arrows

Back to article page