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Table 2 Multivariate analysis (PERMANOVA) of sinus bacterial beta diversity on a weighted UniFrac distance matrix

From: Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences

PERMANOVA (patient cohort)

r2

p value

Dirichlet state (disease a )

0.326

0.001

Dirichlet state (all b )

0.318

0.001

Disease (all)

0.088

0.014

Antibiotic use <3 months (disease)

0.036

0.052

Polyp presence/absence (disease)

0.025

0.152

Anatomic location (all)

0.039

0.185

Age bin 10 year (all)

0.118

0.196

Antibiotic class <3 months (all)

0.260

0.24

Age bin 5 year (all)

0.153

0.367

Antibiotic class <3 months (disease)

0.286

0.399

Anatomic location (disease)

0.0348

0.403

Age bin 10 year (disease)

0.119

0.473

Age bin 5 year (disease)

0.168

0.521

LMS Bin (low/medium/high) (disease)

0.046

0.554

Revision surgery (Y/N) (disease)

0.042

0.668

Age (disease)

0.674

0.799

Lund-Mackay score (LMS) (disease)

0.327

0.906

Age (all)

0.561

0.944

  1. aCRS, CRS+CF, CRS+A
  2. bHealthy, CRS, CRS+A, CRS+CF
  3. Those in boldface are significant (the r2 value indicates the degree of community variance explained by the specific factor)