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Fig. 3 | Microbiome

Fig. 3

From: Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences

Fig. 3

Variation in predicted metagenomes associated with each Dirichlet state. a Heatmap of significantly enriched (red) or depleted (blue) KEGG pathways collapsed at level 3 compared to healthy subjects (negative binomial; p < 0.05, q < 0.10, DS vs. nonCRS). For visualization, read counts were normalized [log2(x + 1)] and scaled by row. b DSII is significantly functionally depleted, measured by total unique KEGG pathways compared to healthy individuals (permutational t test; q = 0.0025). c Tryptophan metabolism is enriched in DSII [Pseudomonadaceae-defined, (negative binomial; p = 0.021, q = 0.059)] and DSIII(b) [Staphylococcaceae-defined (negative binomial; p = 0.005, q = 0.012)]. d The two-component response system virulence pathway is enriched in DSII [Pseudomonadaceae-defined, (negative binomial; p = 0.0002, q = 0.002)] and DSIII(b) [Staphylococcaceae-defined (negative binomial; p = 0.0002, q = 0.002)]. e PPAR-γ signaling pathway is enriched in DSIII(a) [Corynebacteriaceae-defined (negative binomial; p = 0.003, q = 0.0175)]

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