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Fig. 1 | Microbiome

Fig. 1

From: Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences

Fig. 1

CRS patients (irrespective of lower airway disease status) exhibit similar total bacterial burden compared with healthy subjects; however, their microbiota exhibit significantly reduced richness, evenness and diversity. Comparative analyses of sinus microbiota a bacterial burden; b richness (permutation t test; CRS vs healthy q = 0.006; CRS+A vs healthy, q = 0.0015 CRS+CF vs healthy, q = 0.0015); c Pielou’s evenness (permutation t test; CRS vs healthy q = 0.132, CRS+A vs healthy, q = 0.015 and CRS+CF vs healthy, q = 0.003]), and d Faith’s phylogenetic diversity (permutation t test; CRS vs healthy, q = 0.007, CRS+A vs healthy, q = 0.003 and CRS+CF vs healthy, q = 0.003) indices using V4 16S rRNA amplicon sequencing of healthy, CRS, CRS+A and CRS+CF subjects. Values represent the median +/− 1.5 IQR. e Multivariate permutation testing of principal coordinate analysis using PERMANOVA based on a weighted UniFrac distance matrix of all samples indicates that disease status explains 8.9% of community composition variation (p = 0.001)

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