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Table 3 Brain morphometry differences based on microbiota profiles

From: Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome

IBS 1-HC-like IBS

Brain area

Region of interest

Brain measure

p value

β value

Standard error

Somatosensory network

 pINS

Left posterior ramus of the lateral sulcus

SA

.002

60.73

18.47

 pINS

Right inferior segment of the circular sulcus of the insula

SA

.005

41.00

13.89

 pINS

Right inferior segment of the circular sulcus of the insula

V

.005

120.31

41.20

 pINS

Left posterior ramus of the lateral sulcus

V

.015

117.42

46.39

 pINS

Right long insular gyrus and central sulcus of the insula

MC

.045

−0.01

0.01

 Basal ganglia

Right globus pallidus

V

.007

102.28

36.47

 Motor

Left superior part of the precentral sulcus

CT

.009

−0.06

0.02

 Motor

Right superior part of the precentral sulcus

V

.006

−246.50

84.96

 Motor

Right superior part of the precentral sulcus

SA

.017

−96.24

39.02

 Motor

Right superior part of the precentral sulcus

CT

.026

−0.06

0.03

 Motor

Right subcentral gyrus (central operculum) and sulci

CT

.020

−0.08

0.03

 aINS

Left anterior segment of the circular sulcus of the insula

CT

.024

−0.09

0.04

 aINS

Right anterior segment of the circular sulcus of the insula

CT

.029

−0.13

0.06

 aINS

Right anterior segment of the circular sulcus of the insula

SA

.004

45.65

15.12

 aINS

Right anterior segment of the circular sulcus of the insula

V

.044

79.04

38.16

IBS1 - HC

 pINS

Left long insular gyrus and central sulcus of the insula

V

.009

81.33

30.10

 pINS

Left long insular gyrus and central sulcus of the insula

SA

.011

20.87

7.93

 pINS

Right superior segment of the circular sulcus of the insula

CT

.045

−0.05

0.02

 pINS

Left superior segment of the circular sulcus of the insula

CT

.042

−0.05

0.02

 aINS

Right anterior segment of the circular sulcus of the insula

CT

.003

−0.16

0.05

 aINS

Right anterior segment of the circular sulcus of the insula

SA

.002

43.67

13.51

 Somatomotor

Left central sulcus

CT

.043

0.04

0.02

 Somatomotor

Right central sulcus

CT

.033

0.04

0.02

HC-like IBS - HC

 Somatosensory

Left postcentral sulcus

CT

.005

0.06

0.02

 Somatosensory

Right postcentral sulcus

CT

.011

0.05

0.02

 Somatomotor

Right central sulcus

CT

.009

0.05

0.02

 Somatomotor

Left central sulcus

CT

.018

0.04

0.02

 pINS

Right inferior segment of the circular sulcus of the insula

V

.001

−122.97

35.48

 pINS

Right inferior segment of the circular sulcus of the insula

SA

.031

−28.23

12.75

 pINS

Right inferior segment of the circular sulcus of the insula

CT

.022

−0.07

0.03

 pINS

Left posterior insula gyrus

CT

.037

0.08

0.04

 pINS

Left long insular gyrus and central sulcus of the insula

MC

.035

0.01

0.01

 pINS

Right long insular gyrus and central sulcus of the insula

MC

.011

0.01

0.01

 pINS

Left posterior ramus of the lateral sulcus

SA

.034

−37.78

17.27

 Basal ganglia

Right nucleus accumbens

V

.029

−39.23

17.45

  1. This table contains results of the contrast analysis within the framework of the general linear model. Contrast were coded based on the three level cluster factor; IBS1-HC-like IBS (1 -1 0), IBS1-HC (1 0 -1), HC-like IBS-HC (0 1 -1). As such positive beta values indicate greater values in the first group listed. Negative values reflect greater value in the second group
  2. Abbreviations: INS anterior insula, pINS posterior insula, CT cortical thickness, SA surface area, V volume, MC mean curvature