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Table 3 Brain morphometry differences based on microbiota profiles

From: Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome

IBS 1-HC-like IBS
Brain area Region of interest Brain measure p value β value Standard error
Somatosensory network
 pINS Left posterior ramus of the lateral sulcus SA .002 60.73 18.47
 pINS Right inferior segment of the circular sulcus of the insula SA .005 41.00 13.89
 pINS Right inferior segment of the circular sulcus of the insula V .005 120.31 41.20
 pINS Left posterior ramus of the lateral sulcus V .015 117.42 46.39
 pINS Right long insular gyrus and central sulcus of the insula MC .045 −0.01 0.01
 Basal ganglia Right globus pallidus V .007 102.28 36.47
 Motor Left superior part of the precentral sulcus CT .009 −0.06 0.02
 Motor Right superior part of the precentral sulcus V .006 −246.50 84.96
 Motor Right superior part of the precentral sulcus SA .017 −96.24 39.02
 Motor Right superior part of the precentral sulcus CT .026 −0.06 0.03
 Motor Right subcentral gyrus (central operculum) and sulci CT .020 −0.08 0.03
 aINS Left anterior segment of the circular sulcus of the insula CT .024 −0.09 0.04
 aINS Right anterior segment of the circular sulcus of the insula CT .029 −0.13 0.06
 aINS Right anterior segment of the circular sulcus of the insula SA .004 45.65 15.12
 aINS Right anterior segment of the circular sulcus of the insula V .044 79.04 38.16
IBS1 - HC
 pINS Left long insular gyrus and central sulcus of the insula V .009 81.33 30.10
 pINS Left long insular gyrus and central sulcus of the insula SA .011 20.87 7.93
 pINS Right superior segment of the circular sulcus of the insula CT .045 −0.05 0.02
 pINS Left superior segment of the circular sulcus of the insula CT .042 −0.05 0.02
 aINS Right anterior segment of the circular sulcus of the insula CT .003 −0.16 0.05
 aINS Right anterior segment of the circular sulcus of the insula SA .002 43.67 13.51
 Somatomotor Left central sulcus CT .043 0.04 0.02
 Somatomotor Right central sulcus CT .033 0.04 0.02
HC-like IBS - HC
 Somatosensory Left postcentral sulcus CT .005 0.06 0.02
 Somatosensory Right postcentral sulcus CT .011 0.05 0.02
 Somatomotor Right central sulcus CT .009 0.05 0.02
 Somatomotor Left central sulcus CT .018 0.04 0.02
 pINS Right inferior segment of the circular sulcus of the insula V .001 −122.97 35.48
 pINS Right inferior segment of the circular sulcus of the insula SA .031 −28.23 12.75
 pINS Right inferior segment of the circular sulcus of the insula CT .022 −0.07 0.03
 pINS Left posterior insula gyrus CT .037 0.08 0.04
 pINS Left long insular gyrus and central sulcus of the insula MC .035 0.01 0.01
 pINS Right long insular gyrus and central sulcus of the insula MC .011 0.01 0.01
 pINS Left posterior ramus of the lateral sulcus SA .034 −37.78 17.27
 Basal ganglia Right nucleus accumbens V .029 −39.23 17.45
  1. This table contains results of the contrast analysis within the framework of the general linear model. Contrast were coded based on the three level cluster factor; IBS1-HC-like IBS (1 -1 0), IBS1-HC (1 0 -1), HC-like IBS-HC (0 1 -1). As such positive beta values indicate greater values in the first group listed. Negative values reflect greater value in the second group
  2. Abbreviations: INS anterior insula, pINS posterior insula, CT cortical thickness, SA surface area, V volume, MC mean curvature