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Fig. 1 | Microbiome

Fig. 1

From: Revised computational metagenomic processing uncovers hidden and biologically meaningful functional variation in the human microbiome

Fig. 1

Relative normalization masks functional variability. a Shown is a scatter plot of the coefficient of variation (CoV) in the abundance of pathways across gut samples from the Human Microbiome Project, normalized either by relative normalization (x-axis) or by MUSiCC-based normalization (y-axis). Each point represents a single pathway. GG glycolysis/gluconeogenesis, R ribosome, ATB aminoacyl-tRNA biosynthesis; RP RNA polymerase. b, c Scatter plots showing the fold change in abundance of each sample from the average abundance across all gut samples, normalized either by relative normalization (blue) or by MUSiCC-based normalization (orange), for the glycolysis/gluconeogenesis (b) and the RNA polymerase (c) pathways. Each point represents a single sample and samples are ordered according to their MUSiCC-based fold change

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