TY - JOUR AU - Bindels, Laure B. AU - Segura Munoz, Rafael R. AU - Gomes-Neto, João Carlos AU - Mutemberezi, Valentin AU - Martínez, Inés AU - Salazar, Nuria AU - Cody, Elizabeth A. AU - Quintero-Villegas, Maria I. AU - Kittana, Hatem AU - de los Reyes-Gavilán, Clara G. AU - Schmaltz, Robert J. AU - Muccioli, Giulio G. AU - Walter, Jens AU - Ramer-Tait, Amanda E. PY - 2017 DA - 2017/02/07 TI - Resistant starch can improve insulin sensitivity independently of the gut microbiota JO - Microbiome SP - 12 VL - 5 IS - 1 AB - Obesity-related diseases, including type 2 diabetes and cardiovascular disease, have reached epidemic proportions in industrialized nations, and dietary interventions for their prevention are therefore important. Resistant starches (RS) improve insulin sensitivity in clinical trials, but the mechanisms underlying this health benefit remain poorly understood. Because RS fermentation by the gut microbiota results in the formation of physiologically active metabolites, we chose to specifically determine the role of the gut microbiota in mediating the metabolic benefits of RS. To achieve this goal, we determined the effects of RS when added to a Western diet on host metabolism in mice with and without a microbiota. SN - 2049-2618 UR - https://doi.org/10.1186/s40168-017-0230-5 DO - 10.1186/s40168-017-0230-5 ID - Bindels2017 ER -