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Fig. 7 | Microbiome

Fig. 7

From: Host genetic variation in mucosal immunity pathways influences the upper airway microbiome

Fig. 7

Ingenuity Pathway Analysis (IPA) interaction networks. Networks show genes near nasal mbQTLs are enriched for mucosal immunity pathways. Two significant networks (p < 10−25) are presented. a Network one is centered on SMAD2 and ERK1/2 (p < 10−43; 21 genes). b Network two is a highly connected network centered on IL2RA, STAT5a/b, and IL12, among others. This network contains many of the key regulators of mucosal immunity (p < 10−29; 17 genes). Node color represents genes near microbiome QTL associations in the nasal vestibule (blue) or in the nasopharynx (green); open symbols are genes added by IPA. Edges represent direct (solid) and indirect (dashed) interactions in the IPA Knowledge Base database. Node shapes correspond to functional classes of gene products: concentric circles for groups or complexes, diamonds for enzymes, rectangles for transcriptional regulators or modulators, ovals for trans-membrane receptors, and circles for other

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