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Table 4 Minimal inhibitory concentrations for the tested isolates

From: Resilient microorganisms in dust samples of the International Space Station—survival of the adaptation specialists

Antibiotics Isolate pH 5_R2_1_I_A
Methylobacterium tardum
pH 5_R2_1_I_B
Bradyrhizobium erythrophlei
pH 5_R2_1_II_A
Cupriavidus metallidurans
pH 5_R2_2_I_B
Brevibacterium halotolerans
pH 5_R2_2_I_A
Bacillus subtilis
pH 5_R2_2_II_A
Bacillus subtilis
pH 5_R2_5_I_B
Bacillus licheniformis
pH 7_R2F_2_A
Bacillus pumilus
pH 7_R2F_2_C
Bacillus aerophilus
pH 9_R2_3_II_A
Micrococcus yunnanensis
pH 9_R2_5_I_B
Bacillus pumilus
pH 9_R2_5_II_B
Bacillus clausii
pH 9_R2_5_I_C
Bacillus safensis
r2a5R0,2
Bacillus licheniformis
r2a5R0,5
Bacillus licheniformis
ms2R0,5
Bacillus thermoamylovorans
pH7_anox_R2
Bacillus licheniformis
pH9_R2IIA
Paenibacillus campinasensis
pH9_R2IID
Bacillus timonensis
Max. concentration: 256 μg/ml
 Amoxicillin/clavulanic acid 2 256 a 1.5 2 3 0.5 7 3 0.25 0.75 2 0.19 3 16 12 0.19 3 256 a 2
 Cefotaxime 12 256 a 1 2 8 16 64 256 a 128 0.75 16 32 256 a 24 32 32 256 a 12 32
 Ceftriaxone 1.5 256 a 0.5 1.5 0.38 12 256 a 32 16 0.19 4 12 24 24 12 8 64 12 48
 Linezolid 256 a 256 a 256 a 1 1 0.75 1 2 1.5 1 0.75 1 2 1.5 1 1 2 6 1
 Penicillin G 3 256 a 3 8 0.75 0.5 256 a 0.38 0.064 0.094 256 a 24 0.25 24 6 4 0.75 24 1
 Ampicillin 256 a 256 a 1.5 2 3 16 256 a 2 0.25 0.5 1.5 24 2 24 8 2 3 256 a 2
 Colistin 256* 256a 24 32 32 64 64 48 12 2 32 3 24 32 32 64 24 48 16
 Clarithromycin 2 256a 2 0.094 0.064 0.064 0.38 0.125 0.064 4 0.064 256a 0.5 0.064 256a 256a 0.032 256a 0.032
 Clindamycin 256* 256a 256a 0.5 0.75 0.5 12 3 2 0.25 24 256a 4 4 8 1 4 256a 2
 Doxycycline 1.5 256a 0.064 0.047 0.094 0.19 0.25 0.19 0.094 0.25 0.064 0.25 0.125 0.125 0.25 0.75 0.38 0.125 0.19
 Gentamicin 8 96 32 0.094 0.094 0.75 0.38 0.125 0.064 0.38 0.5 0.064 0.094 0.19 0.75 0.125 0.064 0.75 0.064
 Vancomycin 256a 256a 0.75 256a 1 2 3 1.5 1 0.19 2 0.75 0.75 1 8 2 2 4 1.5
Max. concentration: 32 μg/ml
 Ciprofloxacin 6 32 a 0.016 0.047 0.064 0.064 0.125 0.19 0.094 0.75 0.032 0.75 0.094 0.094 0.047 0.19 0.125 0.125 0.125
 Levofloxacin 3 32 a 0.047 0.094 0.125 0.094 0.19 0.25 0.125 1.5 0.094 2 0.125 0.094 0.064 0.38 0.125 0.094 0.094
 Meropenem 32 a 32 a 0.125 0.064 0.19 0.094 0.19 0.25 0.094 0.47 0.094 1 0.25 19 19 0.38 0.38 3 0.38
 Moxifloxacin 0.25 32 a 0.023 0.016 0.047 0.023 0.032 0.640 0.016 0.38 0.008 0.5 0.023 16 0.012 0.032 0.025 0.047 0.023
 Trimethoprim/sulfamethoxazole 32a 32a 0.064 0.125 0.19 0.19 0.19 0.004 0.004 0.5 0.032 0.047 0.094 0.032 0.032 0.094 0.006 0.75 0.004
  1. Italic underlined: sensitive according to non-species related breakpoints of EUCAST; Bold: resistant according to non-species related breakpoints of EUCAST; Slow growing M. tardum and B. erythrophlei were tested on R2A medium with 2 days incubation time since they did not grow at all on MH medium
  2. aGrew at the tested maximum concentration of the respective antibiotic; concentrations given in: μg/ml