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Table 4 Minimal inhibitory concentrations for the tested isolates

From: Resilient microorganisms in dust samples of the International Space Station—survival of the adaptation specialists

Antibiotics

Isolate

pH 5_R2_1_I_A

Methylobacterium tardum

pH 5_R2_1_I_B

Bradyrhizobium erythrophlei

pH 5_R2_1_II_A

Cupriavidus metallidurans

pH 5_R2_2_I_B

Brevibacterium halotolerans

pH 5_R2_2_I_A

Bacillus subtilis

pH 5_R2_2_II_A

Bacillus subtilis

pH 5_R2_5_I_B

Bacillus licheniformis

pH 7_R2F_2_A

Bacillus pumilus

pH 7_R2F_2_C

Bacillus aerophilus

pH 9_R2_3_II_A

Micrococcus yunnanensis

pH 9_R2_5_I_B

Bacillus pumilus

pH 9_R2_5_II_B

Bacillus clausii

pH 9_R2_5_I_C

Bacillus safensis

r2a5R0,2

Bacillus licheniformis

r2a5R0,5

Bacillus licheniformis

ms2R0,5

Bacillus thermoamylovorans

pH7_anox_R2

Bacillus licheniformis

pH9_R2IIA

Paenibacillus campinasensis

pH9_R2IID

Bacillus timonensis

Max. concentration: 256 μg/ml

 Amoxicillin/clavulanic acid

2

256 a

1.5

2

3

0.5

7

3

0.25

0.75

2

0.19

3

16

12

0.19

3

256 a

2

 Cefotaxime

12

256 a

1

2

8

16

64

256 a

128

0.75

16

32

256 a

24

32

32

256 a

12

32

 Ceftriaxone

1.5

256 a

0.5

1.5

0.38

12

256 a

32

16

0.19

4

12

24

24

12

8

64

12

48

 Linezolid

256 a

256 a

256 a

1

1

0.75

1

2

1.5

1

0.75

1

2

1.5

1

1

2

6

1

 Penicillin G

3

256 a

3

8

0.75

0.5

256 a

0.38

0.064

0.094

256 a

24

0.25

24

6

4

0.75

24

1

 Ampicillin

256 a

256 a

1.5

2

3

16

256 a

2

0.25

0.5

1.5

24

2

24

8

2

3

256 a

2

 Colistin

256*

256a

24

32

32

64

64

48

12

2

32

3

24

32

32

64

24

48

16

 Clarithromycin

2

256a

2

0.094

0.064

0.064

0.38

0.125

0.064

4

0.064

256a

0.5

0.064

256a

256a

0.032

256a

0.032

 Clindamycin

256*

256a

256a

0.5

0.75

0.5

12

3

2

0.25

24

256a

4

4

8

1

4

256a

2

 Doxycycline

1.5

256a

0.064

0.047

0.094

0.19

0.25

0.19

0.094

0.25

0.064

0.25

0.125

0.125

0.25

0.75

0.38

0.125

0.19

 Gentamicin

8

96

32

0.094

0.094

0.75

0.38

0.125

0.064

0.38

0.5

0.064

0.094

0.19

0.75

0.125

0.064

0.75

0.064

 Vancomycin

256a

256a

0.75

256a

1

2

3

1.5

1

0.19

2

0.75

0.75

1

8

2

2

4

1.5

Max. concentration: 32 μg/ml

 Ciprofloxacin

6

32 a

0.016

0.047

0.064

0.064

0.125

0.19

0.094

0.75

0.032

0.75

0.094

0.094

0.047

0.19

0.125

0.125

0.125

 Levofloxacin

3

32 a

0.047

0.094

0.125

0.094

0.19

0.25

0.125

1.5

0.094

2

0.125

0.094

0.064

0.38

0.125

0.094

0.094

 Meropenem

32 a

32 a

0.125

0.064

0.19

0.094

0.19

0.25

0.094

0.47

0.094

1

0.25

19

19

0.38

0.38

3

0.38

 Moxifloxacin

0.25

32 a

0.023

0.016

0.047

0.023

0.032

0.640

0.016

0.38

0.008

0.5

0.023

16

0.012

0.032

0.025

0.047

0.023

 Trimethoprim/sulfamethoxazole

32a

32a

0.064

0.125

0.19

0.19

0.19

0.004

0.004

0.5

0.032

0.047

0.094

0.032

0.032

0.094

0.006

0.75

0.004

  1. Italic underlined: sensitive according to non-species related breakpoints of EUCAST; Bold: resistant according to non-species related breakpoints of EUCAST; Slow growing M. tardum and B. erythrophlei were tested on R2A medium with 2 days incubation time since they did not grow at all on MH medium
  2. aGrew at the tested maximum concentration of the respective antibiotic; concentrations given in: ÎĽg/ml