Staphylococcal species heterogeneity in the nasal microbiome following antibiotic prophylaxis revealed by tuf gene deep sequencing

Table 1 Demographic summary of study participants

Antibiotic surgical prophylaxis received	Antibiotic dosage	Patient study ID	Age (years)	Sex	S. aureus nasal carriage detected by conventional culture on admission	Surgical speciality	Surgical procedure	Sample days
No antibiotics		25	79	Female	No	Orthopaedic	None	5
		99	52	Male	Yes	Cardiology	Angioplasty	4
		101	83	Female	No	Cardiology	Angioplasty	4
		105	63	Male	Yes	Cardiology	Angioplasty	5
		111	68	Female	Yes	Cardiology	Angioplasty	5
		113	79	Female	No	Cardiology	Angioplasty	3
Flucloxacillin (1 g) and gentamicin (160 mg)	Single dose IV on induction, and 2 further doses of flucloxacillin (1 g) post op at 6-h intervals	34	87	Female	No		Gamma Nail	7
		36	87	Female	No	Orthopaedic	Gamma Nail	7
		42	88	Female	Yes	Orthopaedic	Dynamic Hip Screw	7
		51	82	Female	No	Orthopaedic	Dynamic Hip Screw	5
		56	72	Female	No	Orthopaedic	Open Reduction of internal fracture of wrist and K wires	7
		61	88	Male	Yes	Orthopaedic	Total knee replacement	5
		61	88	Male	Yes	Orthopaedic	Total knee replacement	5
Teicoplanin (400 mg) +/− gentamicin (160 mg)	Single dose IV on induction	35^b	80	Female	No	Orthopaedic	Hemiarthroplasty	7
		37^b	91	Female	Yes	Orthopaedic	Hemiarthroplasty	7
		65^a	76	Female	No	Orthopaedic	Total hip replacement	4
		86^b	71	Male	Yes	Orthopaedic	Total hip replacement	4
		90^a	81	Female	Yes	Orthopaedic	Hemiarthroplasty	5
		93^a	89	Female	Yes	Orthopaedic	Hemiarthroplasty	4

ISSN: 2049-2618