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Fig. 2 | Microbiome

Fig. 2

From: Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies

Fig. 2

OTU sparsity vs. p value. Scatterplots of OTU sparsity vs p value with panels representing each differential relative abundance test method in feces dataset A1, with 50% cases. Colored line represents the LOESS regression on data. False positive rate (FPR) is defined as the fraction of OTUs with p < 0.05. Each differential relative abundance test represents the median FPR for that method, out of all 150 permutations. Contour lines indicate point density and can be compared to a hypothetical null distribution of p values demonstrated in the final panel (“Random uniform”)

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Microbiome

ISSN: 2049-2618

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