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Fig. 5 | Microbiome

Fig. 5

From: Colitis susceptibility in p47phox−/− mice is mediated by the microbiome

Fig. 5

p47phox−/− mice cohoused with B6Tac mice maintain increased susceptibility to DSS colitis. Changes in body weight (a), disease activity index (b), and survival (c) were assessed daily (B6Tac cohoused with p47phox−/− (n = 8); p47phox−/− cohoused with B6Tac (n = 8), p47phox−/− (n = 28); B6Tac (n = 20)). Significance for comparisons between cohoused mice was determined using the Mann-Whitney U test (*p < 0.05) and a log-rank test for survival (p = 0.06). d Colonic tissue sections were blindly scored for inflammation, depth of injury, and crypt damage on day 9 (B6Tac cohoused with p47phox−/− (n = 8); p47phox−/− cohoused with B6Tac (n = 8); (p = 0.49)). e Bacterial translocation to MLNs was determined on day 9. The number of CFUs per MLN is shown (B6Tac cohoused with p47phox−/− (n = 4); p47phox−/− cohoused with B6Tac (n = 4); p = 0.03)). Pie charts represent the proportion of mice per group where the cultured MLN grew one or more of the listed bacterial species. For all panels, data were generated from 2 independent experiments (except e)

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