Fig. 1
From: Colitis susceptibility in p47phox−/− mice is mediated by the microbiome
p47phox−/− mice have increased susceptibility to DSS colitis. Changes in body weight (a), disease activity index (b), and survival (c) were assessed daily (B6Tac (n = 15); p47phox−/− (n = 28)). Significance was determined using the Mann-Whitney U test (*p < 0.05) and log-rank test for survival (p = 0.0003). d Colonic tissue sections were blindly scored for inflammation, depth of injury, and crypt damage on day 9 (B6Tac (n = 15); p47phox−/− (n = 17); (p = 0.04)). e Representative distal colon sections stained with H&E (original magnification X 10). f Bacterial translocation to MLNs was determined on day 9. The number of CFUs per MLN is shown (B6Tac (n = 5); p47phox−/− (n = 3); (p = 0.04)). Pie charts represent the proportion of mice per group where the cultured MLN grew one or more of the listed bacterial species. For all panels, data are representative of 4 independent experiments (except f)