Table 3 Pathways significantly enriched in ‘core’ microbiome enzymes
Pathway name | Pathway classa | p valueb | Core enzymes in pathway | Total enzymes in pathway |
|---|---|---|---|---|
Aminoacyl-tRNA biosynthesis | O | 3.57E-08 | 22 | 32 |
Purine metabolism | NT | 1.49E-06 | 44 | 100 |
Peptidoglycan biosynthesis | G | 4.30E-06 | 12 | 15 |
Glycolysis/gluconeogenesis | C | 2.89E-05 | 23 | 45 |
Alanine, aspartate and glutamate metabolism | AA | 4.24E-05 | 22 | 43 |
Valine, leucine and isoleucine biosynthesis | AA | 8.75E-05 | 12 | 18 |
Pyrimidine metabolism | NT | 2.89E-04 | 27 | 63 |
Phenylalanine, tyrosine and tryptophan biosynthesis | AA | 6.27E-04 | 15 | 29 |
Pentose phosphate pathway | C | 7.05E-04 | 17 | 35 |
Carbon fixation pathways in prokaryotes | E | 2.22E-03 | 17 | 38 |
One carbon pool by folate | CO | 3.21E-03 | 12 | 24 |
Lysine biosynthesis | AA | 3.32E-03 | 13 | 27 |
Pyruvate metabolism | C | 3.37E-03 | 24 | 62 |
Fatty acid biosynthesis | L | 3.88E-03 | 9 | 16 |
Citrate cycle (TCA cycle) | C | 4.76E-03 | 11 | 22 |
Amino sugar and nucleotide sugar metabolism | C | 5.66E-03 | 30 | 85 |
Oxidative phosphorylation | E | 8.48E-03 | 7 | 12 |
Drug metabolism—other enzymes | X | 2.34E-02 | 9 | 20 |
Cysteine and methionine metabolism | AA | 2.55E-02 | 21 | 61 |
Polyketide sugar unit biosynthesis | T | 2.74E-02 | 4 | 6 |
Streptomycin biosynthesis | S | 3.48E-02 | 8 | 18 |
Folate biosynthesis | CO | 3.61E-02 | 7 | 15 |