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Table 1 Pathways enriched in transcripts displaying large (>fivefold) differences in relative expression between mouse cecal wall and cecal flush samples

From: Metatranscriptomic analysis of diverse microbial communities reveals core metabolic pathways and microbiome-specific functionality

   Fold change in expression Differentially expressed genes Matched ECs/total ECs in pathway
   Genes up-regulated in cecal wall Genes up-regulated in cecal flush
Pathway p value 5–10 10–20 >20 5–10 10–20 >20
Glycolysis/gluconeogenesis 9.35E-07 14 5 3 5 4 1 32 11/45
Methane metabolism 6.44E-05 10 5 3 4 5 2 29 11/68
Carbon fixation in photosynthetic organisms 1.00E-04 8 1 2 4 0 0 15 5/25
One carbon pool by folate 2.88E-04 4 3 0 1 2 0 10 6/24
Starch and sucrose metabolism 4.59E-04 5 4 2 3 3 0 17 10/71
Alanine, aspartate and glutamate metabolism 1.43E-03 9 1 0 0 1 0 11 7/43
Citrate cycle (TCA cycle) 1.52E-03 4 0 2 2 1 0 9 5/22
Pyruvate metabolism 3.08E-03 7 0 2 1 1 1 12 8/62
Amino sugar and nucleotide sugar metabolism 6.63E-03 5 3 1 1 3 2 15 9/85
Oxidative phosphorylation 1.10E-02 2 3 1 0 3 0 9 3/12
Purine metabolism 3.08E-03 10 0 0 2 0 2 14 9/100
Propanoate metabolism 3.37E-02 3 0 0 0 1 1 5 5/45
Valine, leucine and isoleucine biosynthesis 3.40E-02 1 1 0 0 1 2 5 3/18
Aminoacyl-tRNA biosynthesis 3.85E-02 2 0 0 1 0 3 6 4/32
Histidine metabolism 4.25E-02 1 3 0 1 0 0 5 4/33
Drug metabolism—other enzymes 4.49E-02 3 0 0 0 0 0 3 3/20
Other glycan degradation 4.88E-02 1 1 0 0 0 0 2 2/9