Fig. 5

Local differences within metabolic models and their sub-type-specific pathways. The metabolic distance was determined according to the presence of specific reactions in the model (a). t-SNE was performed to obtain a low dimensional representation of the local differences within taxonomic groups which are represented by the different colors. Sub-types are defined based on hierarchical clustering of the reaction similarities. Members of one sub-type are connected with lines which originate from the cluster centroid. The ellipses represent confidence intervals of the clusters with a certainty of 95 %. Distinguished pathways within sub-types include the genera Lactobacillus (b), Bifidobacterium (c), and Bacteroides (d). The pathways occurring in only one of the sub-types are framed by boxes carrying the corresponding cluster name. Reactions within pathways are represented by black arrows. GAP glycerol-3-phosphate, PEPG peptidoglycan, PGP phosphatidylglycerophosphate, PG phosphatidylglycerol, APG 1-Acyl-sn-glycero-3-phosphoglycerol, TTDCA tetradecanoate, HDCA heptadecanoate, OCDCA octadecanoate