Skip to main content
Fig. 1 | Microbiome

Fig. 1

From: Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis

Fig. 1

Infection with N. brasiliensis induces characteristic alterations in intestinal expression of type 2 cytokines, markers for M2 macrophages, and antimicrobial peptides and mucins. N. brasiliensis-infected mice were euthanized at day 11 post-inoculation with infective larvae. qPCR was carried out to examine gene expression of IL-13, Fizz1, and YM-1 in the jejunum (a) and ileum (b), as well as selected AMP and mucins in the ileum (c). The fold change is relative to vehicle after normalization to 18S rRNA. Data shown in bar graphs are the mean ± s.e.m. Two-tailed Student’s t-test was used for comparisons between infected and uninfected mice. *P < 0.05, **P < 0.01, ***P < 0.001 versus respective vehicle (n = 10 for vehicle group and n = 9 for N. brasiliensis-infected group). Ang4 angiogenin 4, Defa1 defensin alpha 1, Fizz1 found in inflammatory zone 1, Lyz1/2 lysozymes 1/2, Muc2 mucin 2, Muc5Ac mucin 5 AC, Reg3γ regenerating islet-derived protein 3 gamma, Retnlb resistin-like molecule beta, YM-1

Back to article page